Real-Life Executive and Adaptive Functioning in Adults with Agenesis of the Corpus Callosum

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Agenesis of the corpus callosum (ACC) is a neurological abnormality where the callosal structure is partially or completely absent. This congenital disorder is accompanied by a cognitive and psychosocial syndrome involving mild neurocognitive deficits. However, less is understood with respect to how cognitive deficiencies translate into daily living ability. In this study, effort was made to inspect adaptive behavior in individuals with ACC using the Adaptive Behavior Assessment System, Second Edition (ABAS-II), and behavioral aspects of executive function using the Behavioral Rating Inventory of Executive Function–Adult Version (BRIEF-A). Adult ACC participants and delegated observers completed the ABAS-II. The same observers also completed the BRIEF-A. ABAS-II data was further analyzed to address self-report reliability concerns in ACC.

Results indicated that (a) ACC respondents rated their adaptive ability to be similar to norms, (b) observer respondents rated statistically lower adaptive ability compared to norms in several skill areas, most notably social skills, (c) observer adaptive ratings were statistically below intelligence level, (d) ACC respondents exhibited mildly deficient insight into their adaptive functioning based on discrepancies between self-report and observer-report, (e) mild executive dysfunction was noted in several areas, particularly in metacognition, and (f) certain EF areas predicted overall adaptive behavior and social function. These findings raise awareness regarding adaptive expectations in ACC, and higher order cognitive factors involved in adaptive behavior.

Degree Name

Doctor of Philosophy in Psychology (PhD, Non-Clinical)

First Advisor

Brown, Warren S.

Document Type





Executive functions, Corpus callosum, Agenesis of corpus callosum, Adaptability, Adulthood




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