Diastolic Blood Pressure and Neurodegeneration: Volumetrics and Cognitive Function in a Cognitively Healthy Aging Population
Although cardiovascular risk factors have continued to play a central role in the scientific discussion of dementia, the mechanisms by which these factors influence the development of dementia remain to be discovered. Further, limited research has focused on the unique role diastolic blood pressure (DBP) has on cognitive functioning and brain volume. Thus, the purpose of this study is to investigate the interplay between cardiovascular and pathophysiological risk factors for dementia, by specifically examining the effect elevated DBP within normal blood pressure range (NBPR) has on verbal memory, executive functioning, frontal lobe volume, and hippocampal volume in a cognitively healthy, high functioning, older adult population. Participants were derived from archival data at Huntington Medical Research Institutes (HMRI) with the sample consisting of 35 cognitively healthy, high functioning older adults. Building upon early findings of a significant relationship between DBP NBPR and verbal memory (Staley Shumaker, 2015), simple multiple GLM regressions were conducted to explore the relationships between the independent variable, DBP NBPR, the dependent variables of cognitive functioning, and pathophysiological factors (i.e., frontal volume, hippocampal volume). DBP NBPR was found to be a good predictor of cognitive functioning (i.e., total verbal memory, CVLT-II, Stroop C performance), and frontal lobe volume (i.e., RH frontal pole and total frontal pole volume). A slight trend was noted between DBP NBPR and total hippocampal volume and RH hippocampal volume. RH frontal pole volume and total frontal volume were also found to be significant mediators between DBP NBPR and total verbal memory, and RH frontal pole volume was found to be a significant mediator of DBP NBPR and CVLT-II LDFR z scores.
Amano, Stacy S.
Blood pressure, Executive functions, Older people, Cognitive neuroscience, Neurobehavioral disorders
Material hosted by ProQuest subject to copyright