Title

Presymptomatic Alzheimer’s Pathology: Neuroanatomical Structural Volumes and Executive Functioning

Publication Date

2-2018

Abstract

Researchers have observed that executive functioning ability declines before memory among individuals with presymptomatic Alzheimer’s pathology. Whether this change in cognitive ability is associated with earlier neuroanatomical structural change is explored in the current study. Specifically, the purpose of the current study was to investigate earlier neuroanatomical volume changes in the hippocampus, precuneus, orbitofrontal cortex, and gray matter among individuals with presymptomatic Alzheimer’s pathology. Participants included 21 cognitively healthy older adults with normal levels of cerebrospinal fluid (CSF) β-amyloid and tau (CH-NAT) and 18 cognitively healthy individuals with pathological levels of CSF β-amyloid and tau (CH-PAT), designated as the presymptomatic Alzheimer’s pathology group. Study findings suggest that individuals in the CH-PAT group had overall smaller volume levels among all neuroanatomical structures analyzed than those in the CH-NAT group, particularly in the right lateral orbitofrontal cortex. Members of the CH-PAT group also displayed poorer executive functioning ability. However, poorer executive functioning ability was associated with smaller left hippocampal volume among females, but not males, in the CH-NAT group.

Degree Name

Doctor of Philosophy in Clinical Psychology (PhD)

First Advisor

Amano, Stacy S.

Document Type

Dissertation

Language

English

Keywords

Alzheimer's disease, Executive functions, Neuroanatomy

Disciplines

Psychology

Comments

Public Access: If you attend a college or university, you may be granted access for free through your school library subscription to ProQuest Theses & Dissertations. Copies may be available for purchase via ProQuest Dissertations Publishing https://dissexpress.proquest.com/search.html

Upload File

wf_no

Embargo Period

10-22-2018

Share

COinS