Chronic Outcomes in Interhemispheric Transfer Time Among Children With Moderate to Severe Traumatic Brain Injury

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Traumatic brain injury (TBI) frequently results in diffuse axonal injury and other white matter damage. The corpus callosum (CC) is particularly vulnerable to injury following TBI, though the impact of this damage may not be apparent until several months to years following injury. Damage to the CC has been associated with impaired neurocognitive functioning in children with TBI. Event-related potentials were used in this study to measure interhemispheric transfer time (IHTT) as an indicator of CC integrity in 31 youth with moderate/severe TBI (msTBI) at the chronic phase of recovery (i.e., 13-18 months post injury), compared with 22 healthy control youth. Neurocognitive performance was also examined among these groups. At the chronic phase of recovery, TBI group youth overall demonstrated slower IHTTs and worse neurocognitive functioning than youth in the control group. Only a subset of msTBI group children had IHTTs that were outside the range of the healthy controls; however, this impairment in interhemispheric communication was not significantly linked with neurocognitive test performance. Overall, this study demonstrated that msTBI results in longstanding differences in interhemispheric and neurocognitive functioning, but injured children are differentially impacted. For future studies, investigators might examine explanatory mechanisms for differential outcomes following msTBI, including corresponding structural and metabolic changes using advanced imaging techniques.

Degree Name

Doctor of Philosophy in Clinical Psychology (PhD)

First Advisor

Marion, Sarah DeBoard

Document Type





Brain damage, Neural circuitry, Neurophysiology, Cerebral dominance, Corpus callosum




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