Title

Patterns of Regional Cerebral Blood Flow in the Subgenual Cingulate Cortex (BA 25) and the Precuneus (BA 7) of Patients Who Completed Suicide, Patients With ADHD, and Healthy Controls

Publication Date

9-2012

Abstract

Research efforts to identify a neurological biomarker for suicide indicate that individuals who completed suicide have global deficits in neurological activity. Upon examining the subgenual cingulate cortex (BA 25) and the precuneus (BA 7) of individuals who completed suicide, decreases in Regional Cerebral Blood Flow (rCBF) were found (Willeumier, Taylor & Amen, 2011). The current retrospective study was conducted to replicate those findings and to control for rCBF variance accounted for by Attention-Deficit/Hyperactivity Disorder (ADHD). It involved three groups: 27 healthy control participants, 26 participants diagnosed with ADHD, and 25 participants who completed suicide. Using single photon emission computed tomography (SPECT) imaging, each participant's rCBF was measured under both a resting and a concentration trial. It was predicted that, under all conditions, in both the subgenual cingulate cortex (BA 25) and the precuneus (BA 7), a between groups analysis would yield these results: the rCBF of the healthy control group would be significantly greater than that of ADHD participants and both would be significantly greater than the rCBF of suicide completers. Results of the current study revealed that, in all conditions, healthy control participants had significantly higher rCBF in both the subgenual cingulate cortex (BA 25) and the precuneus (BA 7) than participants diagnosed with ADHD, and the group of suicide completers. However, no significant differences were found in the rCBF in either of the cortical regions between participants with ADHD, and the group of suicide completers. This suggests that, when compared with healthy participants, there are deficits in these areas of the brain for both ADHD participants and suicide completers and additional research should be conducted regarding the role of ADHD in suicide completion.

Degree Name

PSYD in Clinical Psychology

First Advisor

Tan, Siang-Yang

Date Uploaded

11-21-2018

Collection Number

Psych0371E

Document Type

Dissertation

File Name

Rader_fuller.psych_0371E_10000

Language

English

Keywords

Suicide, Risk factors, Attention-deficit hyperactivity disorder, Risk factors, Cerebral circulation

Disciplines

Psychology

Rights

Material hosted by ProQuest subject to copyright

Comments

This was uploaded by the David Allan Hubbard Library from the ProQuest Dissertations and Theses (ProQuest). If there are any mistakes in this record, please contact archives@fuller.edu.

ProQuest URL

https://search.proquest.com/docview/1477293823/fulltextPDF/B053E2785EA043F4PQ/1?accountid=11008

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wf_no

Embargo Period

11-21-2018

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